We are interested in the molecular mechanisms that cause leukemias and lymphomas. The scope of our research projects ranges from the elucidation of an epigenetic suppressor mechanism to the characteriziation of leukemogenic signal transduction pathways in the malignant cells.
- 2. 4.13 Sarahs and Florians excellent review on circulating microRNAs is published in Blood! Congratulations! And this is not a joke on the first of April, but rather a spotlight overview on a topic that we believe the community will hear about a lot in the future...
-22. 3.13 Ellen Scheidhauer will join our team as technician: very welcome!
- 7. 2.13 Quan-Xiangs and Rainers work on the allele-specific expression of DAPK1 is accepted in PLOS One - congratulations! They used a multiplexed MassARRAY method to quantitate allele specific expression of DAPK1 that is targeted by DNA-methylation in CLL patients. Their findings add another layer of complexity to regulation of this gene that is central to the pathomechanism of the disease.
- 29.1.13 Angelas and Nupurs manuscript has been accepted by PLOS Genetics! The work brings together a very large body of data from 24 additional coauthors on a tumor suppressor mechanism in chromosomal band 13q14. This locus involves epigenetically controlled long non-coding RNAs and coregulation of miRNAs and candidate tumorsuppressorgenes that all regulate NFkB signaling. Congratulations!
- 7.1.13 Deyan Yosifov will also join our team as PostDoc - welcome to him as well!
- 3.1.13 The new year starts with the acceptance of Sabrinas commentary in Leukemia & Lymphoma: Sportoletti. et. al have found a novel NOTCH1 mutation in CLL that points towards a novel specific regulation of stabilization of the intracellular NOTCH1 fragment in these malignant cells. It will be interesting to see what are the upstream regulators of this stabilization in CLL!