We are interested in the molecular mechanisms that cause leukemias and lymphomas. The scope of our research projects ranges from the elucidation of an epigenetic suppressor mechanism to the characteriziation of leukemogenic signal transduction pathways in the malignant cells.
- 6.12.13 Chris´ landmark work on DNA-methylation patterns in CLL has been accepted in the new high impact journal Cancer Discovery! He could nicely show that genetic heterogeneity frequently coincides with epigenetic heterogeneity, and that in addtion CLL cells harbor an outstanding amount of allele specific methylation. Congratulations!
- 31.10.13 Prof. Killmann has honoured me with the invitation to become editorial board member of "Leukemia". What an opportunity!
- 30.10.13 Veras and Danilos Book chapter on the DROSHA miRNA processing assay has been published - nice!
- 1.8.13 Danilos, Veras and Angelas innovative work on the processing of miRNAs in leukemic cells has been accepted by "Leukemia"! They used two elegant systems to i) first quantify the processing intermediates in a cohort of leukemia patients with real-time PCR and ii) to measure DICER processing activity in primary cells using luciferase constructs with and without a precursor-miRNA hairpin. This is among the first times that a processing defect has been described in malignant cells! Well done.
-14.6.13 Our virtual Helmholtz Institute "Resistance
Mechanisms of Leukemia" is mentioned in a contribution "Research in
Baden-Württemberg" of the journal "DIE ZEIT". How many impact
points do we get for that? ;-)