list of publications

selected

Bhattacharya, S. D., Irina S. Idler, Judith Rauen, Sarah Häbe, Hauke Busch, Annett and T. Z. Habermann, Hartmut Döhner, Stephan Stilgenbauer, D. Mertens (2011), Nurse-like cells show deregulated expression of genes involved in immunocompetence, Br J Haematol, 154:3:349-356, IF 4.597

Allegra, D., Mertens, D. (2011), In-vivo quantification of primary microRNA processing by Drosha with a luciferase based system, Biochem Biophys Res Commun, 406:4: 501-505

Bhattacharya, N., Diener, Idler, Barth, Rauen, Habermann, Zenz, Möller, Döhner, Stilgenbauer, Mertens, D. (2011). Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from the peripheral blood. Leukemia, 25:4: 722-726, IF 8.296

Winkler, D., C. Schneider, M. Zucknick, D. Bogelein, K. Schulze, T. Zenz, J. Mohr, A. Philippen, H. Huber, A. Buhler, A. Habermann, A. Benner, H. Dohner, S. Stilgenbauer and D. Mertens (2010). Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk. Haematologica, 95:11: 1880-1888, IF 6.416

Zenz, T., D. Mertens, R. Kuppers, H. Dohner and S. Stilgenbauer (2010). From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 10:1: 37-50, IF 29.538


Original Articles

31.   Bhattacharya, S. D., Irina S. Idler, Judith Rauen, Sarah Häbe, Hauke Busch, Thorsten Zenz, Annett Habermann, Hartmut Döhner, Stephan Stilgenbauer, D. Mertens (2011), Nurse-like cells show deregulated expression of genes involved in immunocompetence, Br J Haematol154:3:349-356, IF 4.597

30.  Allegra, D., Mertens, D. (2011), In-vivo quantification of primary microRNA processing by Drosha with a luciferase based system, Biochem Biophys Res Commun, 406:4: 501-505

29.  Wittig-Blaich, L. A. K., Thorsten Eismann, Melanie Bewerunge-, P. K. Hudler, Eva Winkler, Wolfgang S.L. Strauss, Raimund Hibst, Rudolf and M. S. Steiner, Daniel Mertens, Holger Sültmann, Rainer Wittig (2011), Prostate matrix restores AKT-phosphorylation and rescues loss of adhesion in hepsin-overexpressing PC3 prostate cancer cells, Neoplasia, in press

28.  Bhattacharya, N., Diener, Idler, Barth, Rauen, Habermann, Zenz, Möller, Döhner, Stilgenbauer, Mertens, D. (2011). Non-malignant B cells and chronic lymphocytic leukemia cells induce a pro-survival phenotype in CD14+ cells from the peripheral blood. Leukemia, 25:4: 722-726, IF 8.296

27.  Winkler, D., C. Schneider, M. Zucknick, D. Bogelein, K. Schulze, T. Zenz, J. Mohr, A. Philippen, H. Huber, A. Buhler, A. Habermann, A. Benner, H. Dohner, S. Stilgenbauer and D. Mertens (2010). Protein expression analysis of chronic lymphocytic leukemia defines the effect of genetic aberrations and uncovers a correlation of CDK4, P27 and P53 with hierarchical risk. Haematologica, 95:11: 1880-1888, IF 6.416

26.  Mohr, H., Fuge, Eldering, Buehler, Winkler, Volden, Kater, Mertens, te Raa, Doehner, Stilgenbauer, Zenz (2010). DNA damage induced transcriptional programme in CLL: biological and diagnostic implications of functional p53 testing. Blood 117:5: 1622-1632, IF 10.555

25.  Philippen, A., S. Diener, T. Zenz, H. Dohner, S. Stilgenbauer and D. Mertens (2010). SYK carries no activating point mutations in patients with chronic lymphocytic leukaemia (CLL). Br J Haematol 150:5: 633-636, IF 4.597

24.  Bhattacharya, N., A. Sarno, I. S. Idler, M. Fuhrer, T. Zenz, H. Dohner, S. Stilgenbauer and D. Mertens (2010). High-throughput detection of nuclear factor-kappaB activity using a sensitive oligo-based chemiluminescent enzyme-linked immunosorbent assay. Int J Cancer 127:2: 404-411, IF 4.722

23.  Giannopoulos, K., D. Mertens, A. Buhler, T. F. Barth, I. Idler, P. Moller, A. Krober, J. Greiner, S. Chocholska, A. Dmoszynska, J. Rolinski, H. Dohner, S. Stilgenbauer and M. Schmitt (2009). The candidate immunotherapeutical target, the receptor for hyaluronic acid-mediated motility, is associated with proliferation and shows prognostic value in B-cell chronic lymphocytic leukemia. Leukemia 23:3: 519-527, IF 8.296

22.  Zenz, T., J. Mohr, E. Eldering, A. P. Kater, A. Buhler, D. Kienle, D. Winkler, J. Durig, M. H. van Oers, D. Mertens, H. Dohner and S. Stilgenbauer (2009). miR-34a as part of the resistance network in chronic lymphocytic leukemia. Blood 113:16: 3801-3808, IF 10.555

21.  Zenz, T., J. Mohr, J. Edelmann, A. Sarno, P. Hoth, M. Heuberger, H. Helfrich, D. Mertens, H. Dohner and S. Stilgenbauer (2009). Treatment resistance in chronic lymphocytic leukemia: the role of the p53 pathway. Leuk Lymphoma 50:3: 510-513, IF 2.397

20.  Zenz, T., S. Habe, T. Denzel, J. Mohr, D. Winkler, A. Buhler, A. Sarno, S. Groner, D. Mertens, R. Busch, M. Hallek, H. Dohner and S. Stilgenbauer (2009). Detailed analysis of p53 pathway defects in fludarabine-refractory chronic lymphocytic leukemia (CLL): dissecting the contribution of 17p deletion, TP53 mutation, p53-p21 dysfunction, and miR34a in a prospective clinical trial. Blood 114:13: 2589-2597, IF 10.555

19.  Loeder, S., T. Zenz, A. Schnaiter, D. Mertens, D. Winkler, H. Dohner, K. M. Debatin, S. Stilgenbauer and S. Fulda (2009). A novel paradigm to trigger apoptosis in chronic lymphocytic leukemia. Cancer Res 69:23: 8977-8986, IF 7.543

18.  Idler, I., K. Giannopoulos, T. Zenz, N. Bhattacharya, M. Nothing, H. Dohner, S. Stilgenbauer and D. Mertens (2009). Lenalidomide treatment of chronic lymphocytic leukaemia patients reduces regulatory T cells and induces Th17 T helper cells. Br J Haematol 148:6: 948-950, IF 4.597

17.  Tschuch, C., A. Schulz, A. Pscherer, W. Werft, A. Benner, A. Hotz-Wagenblatt, L. S. Barrionuevo, P. Lichter and D. Mertens (2008). Off-target effects of siRNA specific for GFP. BMC Mol Biol 9: 60, IF 2.848

16.  Prowatke, I., F. Devens, A. Benner, E. F. Grone, D. Mertens, H. J. Grone, P. Lichter and S. Joos (2007). Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays. Br J Cancer 96:1: 82-88, IF 4.346

15.  Kalla, C., M. O. Scheuermann, I. Kube, M. Schlotter, D. Mertens, H. Dohner, S. Stilgenbauer and P. Lichter (2007). Analysis of 11q22-q23 deletion target genes in B-cell chronic lymphocytic leukaemia: evidence for a pathogenic role of NPAT, CUL5, and PPP2R1B. Eur J Cancer 43:8: 1328-1335, IF 4.121

14.  Wolf, S., D. Mertens, A. Pscherer, P. Schroeter, D. Winkler, H. J. Grone, C. Hofele, K. Hemminki, R. Kumar, G. Steineck, H. Dohner, S. Stilgenbauer and P. Lichter (2006). Ala228 variant of trail receptor 1 affecting the ligand binding site is associated with chronic lymphocytic leukemia, mantle cell lymphoma, prostate cancer, head and neck squamous cell carcinoma and bladder cancer. Int J Cancer 118:7: 1831-1835, IF 4.722

13.  Mertens, D., S. Wolf, C. Tschuch, C. Mund, D. Kienle, S. Ohl, P. Schroeter, F. Lyko, H. Dohner, S. Stilgenbauer and P. Lichter (2006). Allelic silencing at the tumor-suppressor locus 13q14.3 suggests an epigenetic tumor-suppressor mechanism. Proc Natl Acad Sci U S A 103:20: 7741-7746, IF 9.432

12.  Mannherz, O., D. Mertens, M. Hahn and P. Lichter (2006). Functional screening for proapoptotic genes by reverse transfection cell array technology. Genomics 87:5: 665-672, 3.327

11.  Kienle, D., A. Benner, A. Krober, D. Winkler, D. Mertens, A. Buhler, T. Seiler, U. Jager, P. Lichter, H. Dohner and S. Stilgenbauer (2006). Distinct gene expression patterns in chronic lymphocytic leukemia defined by usage of specific VH genes. Blood 107:5: 2090-2093, IF 10.555

10.  Henrich, K. O., M. Fischer, D. Mertens, A. Benner, R. Wiedemeyer, B. Brors, A. Oberthuer, F. Berthold, J. S. Wei, J. Khan, M. Schwab and F. Westermann (2006). Reduced expression of CAMTA1 correlates with adverse outcome in neuroblastoma patients. Clin Cancer Res 12:1: 131-138, IF 6.747

9.  Adamowicz, M., B. Radlwimmer, R. J. Rieker, D. Mertens, M. Schwarzbach, P. Schraml, A. Benner, P. Lichter, G. Mechtersheimer and S. Joos (2006). Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas. Genes Chromosomes Cancer 45:9: 829-838, IF 3.858

8.  Kienle, D. L., C. Korz, B. Hosch, A. Benner, D. Mertens, A. Habermann, A. Krober, U. Jager, P. Lichter, H. Dohner and S. Stilgenbauer (2005). Evidence for distinct pathomechanisms in genetic subgroups of chronic lymphocytic leukemia revealed by quantitative expression analysis of cell cycle, activation, and apoptosis-associated genes. J Clin Oncol 23:16: 3780-3792, IF 17.793

7.  Kalla, C., H. Nentwich, M. Schlotter, D. Mertens, K. Wildenberger, H. Dohner, S. Stilgenbauer and P. Lichter (2005). Translocation t(X;11)(q13;q23) in B-cell chronic lymphocytic leukemia disrupts two novel genes. Genes Chromosomes Cancer 42:2: 128-143, IF 3.858

6.  Mertens, D., S. Wolf, P. Schroeter, C. Schaffner, H. Dohner, S. Stilgenbauer and P. Lichter (2002). Down-regulation of candidate tumor suppressor genes within chromosome band 13q14.3 is independent of the DNA methylation pattern in B-cell chronic lymphocytic leukemia. Blood 99:11: 4116-4121, IF 10.555

5.  Korz, C., A. Pscherer, A. Benner, D. Mertens, C. Schaffner, E. Leupolt, H. Dohner, S. Stilgenbauer and P. Lichter (2002). Evidence for distinct pathomechanisms in B-cell chronic lymphocytic leukemia and mantle cell lymphoma by quantitative expression analysis of cell cycle and apoptosis-associated genes. Blood 99:12: 4554-4561,  IF 10.555

4.  Wolf, S., D. Mertens, C. Schaffner, C. Korz, H. Dohner, S. Stilgenbauer and P. Lichter (2001). B-cell neoplasia associated gene with multiple splicing (BCMS): the candidate B-CLL gene on 13q14 comprises more than 560 kb covering all critical regions. Hum Mol Genet 10:12: 1275-1285., IF 7.386

3.  Bullinger, L., E. Leupolt, C. Schaffner, D. Mertens, M. Bentz, P. Lichter, H. Dohner and S. Stilgenbauer (2000). BCL10 is not the gene inactivated by mutation in the 1p22 deletion region in mantle cell lymphoma. Leukemia 14:8: 1490-1492, IF 8.296

2.  Mertens, D., S. Wolf, L. Bullinger, S. Ohl, C. Schaffner, H. Dohner, S. Stilgenbauer and P. Lichter (2000). BCMSUN, a candidate gene for B-cell chronic lymphocytic leukemia and mantle-cell lymphoma, has an independently expressed homolog on 1p22- p31, BCMSUN-like. Int J Cancer 88:5: 692-697., IF 4.722

1. Lammer, C., S. Wagerer, R. Saffrich, D. Mertens, W. Ansorge and I. Hoffmann (1998). The cdc25B phosphatase is essential for the G2/M phase transition in human cells. J Cell Sci 111 (Pt 16): 2445-2453, IF 6.144

 

Review Articles

11. Schnaiter, A., Mertens, D., Stilgenbauer, S. (2011),  Genetics of Chronic Lymphocytic Leukemia, Clinics in Laboratory Medicine, in press.

10. Giannopoulos, K., Mertens, D., Stilgenbauer, S. (2011), Treating chronic lymphocytic leukemia with Thalidomide and Lenalidomide, Current Opinion in Pharmacotherapy, in press.

9. Mertens, D., Bullinger, L., Stilgenbauer, S. (2011), Chronic Lymphocytic Leukemia - Genomics Lead the Way, Haematologica, 96(10):1402-5.

8. Stilgenbauer, S., Mertens, D. (2011), Toward chemotherapy-free treatment of CLL, Blood, 118(13), 3451-2.

7.  Idler, N. B., Döhner, H., Stilgenbauer, S., Mertens, D. (2011), Immune modulatory agents in hematopoietic malignancies, Cancer Treatment Reviews, 37 Suppl 1: S2-7.

6.  Zenz, T., D. Mertens, H. Dohner and S. Stilgenbauer (2011), Importance of genetics in chronic lymphocytic leukemia, Blood Rev 25:3: 131-137

5. Zenz, T., D. Mertens, R. Kuppers, H. Dohner and S. Stilgenbauer (2010). From pathogenesis to treatment of chronic lymphocytic leukaemia. Nat Rev Cancer 10:1: 37-50, IF 29.538

4. Zenz, T., D. Mertens and S. Stilgenbauer (2010). Biological diversity and risk-adapted treatment of chronic lymphocytic leukemia. Haematologica 95:9: 1441-1443, IF 6.416

3. Zenz, T., S. Frohling, D. Mertens, H. Dohner and S. Stilgenbauer (2010). Moving from prognostic to predictive factors in chronic lymphocytic leukaemia (CLL). Best Pract Res Clin Haematol 23:1: 71-84, IF 3.134

2. Mertens, D., A. Philippen, M. Ruppel, D. Allegra, N. Bhattacharya, C. Tschuch, S. Wolf, I. Idler, T. Zenz and S. Stilgenbauer (2009). Chronic lymphocytic leukemia and 13q14: miRs and more. Leuk Lymphoma 50:3: 502-505, IF 2.397

1. Zenz, T., D. Mertens, H. Dohner and S. Stilgenbauer (2008). Molecular diagnostics in chronic lymphocytic leukemia - pathogenetic and clinical implications. Leuk Lymphoma 49:5: 864-873, IF 2.397